AURKB-driven dissolution of CIZ1-RNA assemblies from the inactive X chromosome in mitosis
Lewis Byrom, Gabrielle L. Turvey, Adam Dowle, Megan Thomas, Navin Shirodkar, Ben J Green, Brown, Charlotte Ball, Kate E Chapman, Elena Guglielmi, William Dickson, Emma Noon, Sajad Sofi, Justin Ainscough, Alfred A. Antson, Dawn Coverley
This paper shows that AURKB drives the dissolution of CIZ1-RNA assemblies from the inactive X chromosome during mitosis by phosphorylating CIZ1's C-terminal extensions, disrupting its RNA interactions.
Nucleic Acids Research · Jan 22, 2026Peer-reviewedCell Biology