Adam Dowle

A scalable in vitro cell competition model identifies preleukemic super competitor clones

This study develops an in vitro clonal competition model to identify preleukemic TET2-mutant clones that suppress wild-type cells through RAC1-GEF signalling inhibition.

A pH-dependent protein kinase cascade regulates divergent differentiation of Leishmania in the sand fly.

This study identifies a pH-dependent kinase cascade in Leishmania that regulates differentiation into infectious stages, revealing key pathways for acid adaptation and transmission.

Structural basis for covalent inhibition of sulfatases by sulfamate warheads

This paper investigates why aryl sulfatases are inhibited by sulfamate warheads while carbohydrate sulfatases are not, using structural and computational analyses.

Molecular organization of the Chlorella sorokiniana pyrenoid

This study characterizes the pyrenoid structure and molecular components of Chlorella sorokiniana, revealing conserved inorganic carbon delivery machinery and novel proteins involved in pyrenoid assembly and starch tethering.

Aberrant splicing of MBD1 reshapes the epigenome to drive convergent myeloerythroid defects in MDS

This study identifies MBD1-L, an aberrantly spliced transcript in MDS, which drives epigenetic changes leading to myeloerythroid defects, and shows ASO-based targeting can restore erythroid differentiation.

Ubiquitinome dynamics and regulation by DUB2 during Leishmania differentiation

This study maps the Leishmania ubiquitinome and identifies DUB2 as a key regulator of differentiation by modulating ubiquitination of proteins involved in cell motility and metabolism.

Specialised RNA decay fine-tunes monogenic antigen expression in African trypanosomes

The paper identifies three proteins that negatively regulate ESAG transcripts through specialised RNA decay in Trypanosoma brucei, revealing a novel post-transcriptional regulatory mechanism.

Ontogeny-independent expression of LPCAT2 in granuloma macrophages during experimental visceral leishmaniasis

The paper uses multimodal imaging and single-cell transcriptomics to identify LPCAT2-mediated membrane remodeling in granuloma macrophages during visceral leishmaniasis.

AURKB-driven dissolution of CIZ1-RNA assemblies from the inactive X chromosome in mitosis

This paper shows that AURKB drives the dissolution of CIZ1-RNA assemblies from the inactive X chromosome during mitosis by phosphorylating CIZ1's C-terminal extensions, disrupting its RNA interactions.

A non-canonical role for the ATAD2 ortholog BDF7 in nucleolar ribosome maturation and amastigote survival in Leishmania mexicana.

The Androgen Receptor and MYC synergise to modulate the synthesis of Siglec-7 ligands in prostate cancer

This study shows that the androgen receptor and MYC work together to control the production of Siglec-7 ligands in prostate cancer by regulating sialylation and glycopeptide profiles.

Discovery and characterization of cell-permeable inhibitors of Leishmania mexicana CLK1 using an in-cell target engagement assay

This paper identifies and validates cell-permeable inhibitors of Leishmania mexicana CLK1 using a BRET-based assay, showing WZ8040 effectively targets CLK1 with minimal host toxicity.

The mitotic spindle kinase MSK co-ordinates segregation of the nucleus and kinetoplast in Leishmania mexicana

This study identifies MSK as a kinase essential for coordinating nucleus and kinetoplast segregation in Leishmania mexicana, showing its role in mitotic spindle function and cell survival.

DIANNeR: label-free RIME resolves lineage-restricted Glucocorticoid Receptor interactomes in normal human tissues

DIANNeR improves detection of GR interactomes in normal tissues by integrating DIA, ion mobility, and library-free analysis, revealing context-specific networks and previously undetected interactions.

Functional Characterization of a Novel Long Non-Coding RNA in Leishmania braziliensis Identified Through Computational Screening for Conserved RNA Structures

The paper identifies a conserved long non-coding RNA in Leishmania braziliensis and shows its structural importance for parasite fitness and RNA-protein interactions.

Post-translational epigenetics: PRMT7 regulates RNA-binding capacity and protein stability to control Leishmania parasite virulence

The paper identifies PRMT7 as an epigenetic regulator in Leishmania that modifies RNA-binding proteins, affecting mRNA stability and virulence.

The mRNA-bound proteome of Leishmania mexicana: novel genetic insight into an ancient parasite

This study identifies 1,400 mRNA binding proteins in Leishmania mexicana across three lifecycle stages, revealing stage-specific RNA binding and limited correlation between mRNA levels and protein expression.