Multiomics-based assessment of 2D and 3D human iPSC-cardiomyocyte models of insulin resistance demonstrate metabolic and contractile dysfunction that recapitulates diabetic cardiomyopathy.
Ryan D. Carter, Ujang Purnama, Marcos Castro‐Guarda, Claudia N. Montes Aparicio, Anandhakumar Chandran, Richard J. Mbasu, Maxwell A. Ruby, Charlotte Daly, Francesca Meteora Buffa, Lisa C. Heather, Carolyn A. Carr
The paper uses multiomics analysis of 2D and 3D hiPSC-CMs under insulin resistance conditions to show metabolic and contractile dysfunction resembling diabetic cardiomyopathy.
bioRxiv · Nov 20, 2024 · PreprintMolecular Biology