Carolyn A. Carr

Transcriptomic analysis of adult mouse cardiac stromal cells using single-cell qRT-PCR

This study compares two methods for isolating cardiac progenitor cells, finding that the collagenase-trypsin protocol yields more cells and shares a gene expression profile with cardiosphere-derived cells.

Endothelial Slit2 guides the Robo1-positive sympathetic innervation during heart development

This study identifies the Slit2-Robo1 pathway as critical for cardiac sympathetic innervation during development, showing reduced innervation in Slit2-/- and Robo1-/- mice.

microRNA-210 enhances cell survival and paracrine potential for cardiac cell therapy while targeting mitophagy.

This study shows that miR-210 improves cardiac progenitor cell survival and paracrine function by inhibiting apoptosis and mitophagy, and enhancing mitochondrial biogenesis and growth factor secretion.

Multiomics-based assessment of 2D and 3D human iPSC-cardiomyocyte models of insulin resistance demonstrate metabolic and contractile dysfunction that recapitulates diabetic cardiomyopathy.

The paper uses multiomics analysis of 2D and 3D hiPSC-CMs under insulin resistance conditions to show metabolic and contractile dysfunction resembling diabetic cardiomyopathy.