Enzymatic bromination of native peptides for late-stage structural diversification via Suzuki-Miyaura coupling
Haley N. Bridge, Chase L. Radziej, Amy M. Weeks
This study demonstrates the use of engineered halogenase RebH variants to brominate peptides, enabling Suzuki-Miyaura coupling for functional group installation and biological activity tuning.
ACS Chemical Biology · Apr 28, 2026Peer-reviewedBiochemistry