New Mechanistic Insights into Prp5-mediated Prespliceosome Formation
Ching-Yang Kao, Wei-Yü Tsai, Yu-Lun Su, Che-Sheng Chung, Soo-Chen Cheng
This study investigates the roles of Prp5 and Sub2 in prespliceosome formation, showing that ATP binding, not hydrolysis, drives early remodeling events.
bioRxiv · Aug 8, 2025 · PreprintBiochemistry