Improved Protein Encapsulation and Delivery by Lipid Nanoparticles with Refined Ionizable Lipid Content
Eimina Dirvelytė-Valauskė, Modestas Mazerimas, Božena Pavliukevičienė, Neringa Daugelaviciene, Simonas Kutanovas, Ching-Yang Kao, You‐Tzung Chen, Urtė Neniškytė, Rima Budvytytė
This study designs and optimizes lipid nanoparticles for efficient delivery of CRISPR-Cas ribonucleoprotein complexes, showing improved biodistribution and translocation properties in a brain endothelial model.
bioRxiv · Mar 12, 2026 · PreprintBiochemistry