Author

Chek-Ying Tan

Victor Chang Cardiac Research Institute

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

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Genetic & Genomic Medicine· 2 Neuroscience· 1

Signature Assays, Organisms & Methods

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Organism:human· 3 Assay:electronic health records· 2 Approach:statistical model· 2 Research Focus:variant effect prediction· 2 Research Focus:differential expression· 1 Assay:electrophysiology· 1 Approach:experimental assay· 1

Frequent Co-Authors

Chai‐Ann NgiD· 3 shared Jamie I. VandenbergiD· 3 shared Himanshu GoeliD· 2 shared Joanne G. MaiD· 2 shared Lyn Robyn GriffithsiD· 2 shared Neven MaksemousiD· 2 shared Qianyi Shen· 2 shared Abhishek Malhotra· 1 shared

Activity by Year

2024-2026 · peak 2/yr

Co-Author Collaboration Network

10 top collaborators · 34 mutual co-author links

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3 shared papersGenetic & Genomic Medicine

Chai‐Ann NgORCID

Mutual co-authors in cluster

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3 papers

Recent·Most cited

A benign control-calibrated multiparametric functional assay supports CACNA1A variant assessment

Chek-Ying Tan, Neven Maksemous, Joanne G. Ma, Sangavi Sivagnanasundram, Qianyi Shen, Shrey Sharma, Himanshu Goel, Manny Jacobs, Zornitza Stark, Kavitha Kothur, Lyn Robyn Griffiths, Jamie I. Vandenberg, Chai‐Ann Ng

This paper develops a calibrated functional assay to assess CACNA1A variants, showing it can accurately classify pathogenic and benign variants with high specificity and sensitivity.

medRxiv · Oct 14, 2026 · PreprintGenetic & Genomic Medicine

Calibrated high-throughput electrophysiology enables clinical interpretation of CACNA1G missense variants

Rocio K. Finol‐Urdaneta, Chek-Ying Tan, Neven Maksemous, Joanne G. Ma, Paul J. Lockhart, Penny Snell, Abhishek Malhotra, Bryony A. Thompson, Gunjan Garg, Himanshu Goel, Lyn Robyn Griffiths, David J. Adams, Jamie I. Vandenberg, Chai Ann Ng

This paper develops a calibrated electrophysiological framework to classify CACNA1G missense variants, identifying two variants as likely pathogenic and others as benign.

bioRxiv · May 18, 2026 · PreprintNeuroscience

Prognostic Value of Multiplexed Assays of Variant Effect and Automated Patch-clamping for KCNH2-LQTS Risk Stratification

Matthew J. O’Neill, Chai‐Ann Ng, Takanori Aizawa, Luca Sala, Sahej Bains, Annika Winbo, Rizwan Ullah, Qianyi Shen, Chek-Ying Tan, Krystian A. Kozek, Loren R. Vanags, Devyn Mitchell, Alex Shen, Yuko Wada, Asami Kashiwa, , Brett M. Kroncke

This paper evaluates how functional variant data and penetrance estimates improve risk stratification for LQTS in KCNH2 missense variant carriers.

Circulation · Sep 24, 2024Peer-reviewedGenetic & Genomic Medicine