David J. Adams

This paper develops a calibrated electrophysiological framework to classify CACNA1G missense variants, identifying two variants as likely pathogenic and others as benign.

This study investigates the impact of the Kir4.2R28C mutation on channel function and cellular processes, finding it causes loss of function and disrupts protein stability and trafficking.

This study investigates how CaV2.2, GIRK, and HCN channels modulate excitability in somatic and visceral sensory neurons in response to Vc1.1 and baclofen, finding distinct mechanisms in different neuron types.

This study generates human proprioceptor and low-threshold mechanoreceptor neurons from pluripotent stem cells and characterizes their molecular and functional properties.

This study shows that Vc1.1 modulates GIRK1/2 channels via GABAB receptor activation, reducing neuronal excitability and providing insights for non-opioid pain treatments.