De-novo DNA Methylation of Bivalent Promoters Induces Gene Activation through PRC2 Displacement
Henriette O’Geen, Alina Mihalovits, Benjamin D. Brophy, Yang He, Maxwell W. Miller, Chelsey J. Lee, David Jay Segal, Markéta Tomková
The paper shows that DNA methylation in bivalent promoters can activate genes by displacing repressive marks, and this mechanism is relevant in cancer.
bioRxiv · Feb 7, 2025 · PreprintGenomics