Author
University of California, DavisORCID 0000-0001-8962-3105Unclaimed ORCID profile · follow to get notified of new preprints
5 papers
Recent·Most cited
Luke S. Myers, Sarah Christian, Sean G. Simpson…·Scott V. Dindot
This paper describes a pig model of Angelman syndrome that mirrors early developmental symptoms observed in humans.
Henriette O’Geen, Alina Mihalovits, Benjamin D. Brophy…·Markéta Tomková
The paper shows that DNA methylation in bivalent promoters can activate genes by displacing repressive marks, and this mechanism is relevant in cancer.
Orangel J. Gutierrez Fugón, Osman Sharifi, Nicholas G. Heath…·Janine M. LaSalle
The paper integrates CTCF loops, methylome, and transcriptome data from LUHMES neurons to study imprinting dynamics at the 15q11-q13 locus during differentiation.
Scott V. Dindot, Sarah Christian, William J. Murphy…·Jill L. Silverman
This paper describes the development of an antisense oligonucleotide (ASO) therapy targeting the UBE3A-AS transcript to reactivate paternal UBE3A expression in Angelman syndrome models.
S. Jesse Lopez, Benjamin I. Laufer, Ulrika Beitnere…·Janine M. LaSalle
This paper investigates the molecular impacts of UBE3A loss in a novel rat model of Angelman syndrome using systems biology approaches, revealing epigenetic network interactions between maternal and paternal transcripts.