Markéta Tomková

T-World is a computational model of human ventricular myocytes that accurately replicates physiological processes and identifies arrhythmia risks, with applications in drug response prediction.

The paper shows that DNA methylation in bivalent promoters can activate genes by displacing repressive marks, and this mechanism is relevant in cancer.

The paper integrates CTCF loops, methylome, and transcriptome data from LUHMES neurons to study imprinting dynamics at the 15q11-q13 locus during differentiation.

The paper introduces MoToCC, a method to identify critical cell-types associated with neurodevelopmental disorders using genetic modules and single-cell data.

The paper characterizes genetic determinants of context-specific DNA methylation in primary monocytes exposed to inflammatory stimuli, identifying 209 CpGs under genetic control and linking them to disease.

This study shows that the transcription factor MITF interacts with the MRN complex to modulate the DNA damage response in melanoma, contributing to cancer predisposition.

This paper introduces a bisulfite-free method for base-resolution sequencing of 5mC and 5hmC, offering higher quality and lower cost compared to traditional bisulfite sequencing.