DNMT1-Mediated Epigenetic Reprogramming Drives KMT2A Amplifications and Rearrangements
Madison A. Lineberger, Zach H. Gray, Benjamin I. Ferman, Erin O Donnell, Rebecca G. Smith, Kathleen L Schiela, Anushka Udara, Kashish Chetal, Chloe Azadegan, Monika Maria Toma, Ethan Sumner, John Santoro, Christopher Miranda, Manna Ahmed, Jade Wilson, , Johnathan R. Whetstine
The paper identifies a DNA-histone methylation axis that drives KMT2A amplifications and rearrangements in leukemia, revealing therapeutic targets.
bioRxiv · Sep 22, 2026 · PreprintCancer Biology