Author
Fox Chase Cancer CenterORCID 0000-0003-0555-4283Unclaimed ORCID profile · follow to get notified of new preprints
4 papers
Recent·Most cited
Madison A. Lineberger, Zach H. Gray, Benjamin I. Ferman…·Johnathan R. Whetstine
The paper identifies a DNA-histone methylation axis that drives KMT2A amplifications and rearrangements in leukemia, revealing therapeutic targets.
Adria Hasan, Elena V. Demidova, Pragya Priyadarshini…·Sanjeevani Arora
The paper identifies a germline KDM3C polymorphism linked to impaired DNA repair and increased sensitivity to chemoradiotherapy in cancers like rectal and head and neck squamous cell carcinomas.
Rebecca G. Smith, Yu Fu, Kathleen L Schiela…·Yu Liu
This study shows histone hyperacetylation disrupts TAD intra-interactions but preserves CTCF-CTCF loops, revealing distinct cohesin populations with different sensitivity to acetylation.
Mariam Ahmed Fouad, Christopher S Parry, Sven A. Miller…·John Karanicolas
The paper identifies small molecules that stabilize and restore function to missense-mutated VHL proteins in kidney cancer cells.