Rebecca G. Smith

The paper identifies a DNA-histone methylation axis that drives KMT2A amplifications and rearrangements in leukemia, revealing therapeutic targets.

The paper integrates epigenomic features to identify chromatin-state classes and shows Polycomb-associated chromatin drives cell-type-specific differences.

This study shows histone hyperacetylation disrupts TAD intra-interactions but preserves CTCF-CTCF loops, revealing distinct cohesin populations with different sensitivity to acetylation.

This study shows that cohesin residence time, not just its presence, determines how histone hyperacetylation affects 3D genome structure.

This study examines how systemic respiratory infections alter transcriptional patterns in the Alzheimer's disease brain, identifying gene expression changes and pathways linked to immune and vascular responses.

This study investigates JAKMIP1's role in neuronal IL-6/STAT3 signaling and its implications for Dup15q syndrome, finding that JAKMIP1 deficiency impairs signaling and neuritogenesis.

The paper identifies a DNA methylation module in the substantia nigra associated with depressive symptoms in Parkinson's disease.

The paper develops a multivariate methylation risk score using blood DNA methylation data to predict dementia risk and cognitive impairment in Alzheimer's and Parkinson's disease cohorts.

The paper identifies DNA methylation signatures in Alzheimer's disease cortex, showing most changes are driven by non-neuronal cell types.

This study performs a meta-analysis of DNA methylation data from Alzheimer's disease patients to identify differentially methylated loci across brain regions and cortex.

The paper identifies an epigenomic factor linked to reduced activated microglia that mitigates the risk of Alzheimer's disease in APOE ε4 carriers.

The paper develops a novel DNA methylation clock optimized for human cortex tissue, outperforming existing clocks and highlighting issues with previous associations between DNA methylation age and neurodegenerative phenotypes.