Kashish Chetal

The paper identifies a DNA-histone methylation axis that drives KMT2A amplifications and rearrangements in leukemia, revealing therapeutic targets.

The paper identifies a splicing mechanism in AML independent of mutations, showing it drives poor prognosis and can be targeted with PRMT5 inhibition.

The paper shows that reduced synMuv B gene activity in C. elegans enhances RNA interference against viral infection.

The paper uses multiomic analysis of leukemic clones in a mouse model to identify growth regulators and validate their roles in AML.

The paper uses transcriptomic data from amniotic fluid and fetal tissues to identify biomarkers of fetal maturity in rhesus macaques, showing that cell-free RNA can predict lung compliance and gestational age.

This study shows that blocking inflammation in preterm primates prevents lung injury, preserving alveolar structure and function similar to chronic lung disease in newborns.

This study investigates circadian rhythms in human intestinal organoids, showing circadian phase-dependent necrotic cell death responses to TcdB and identifying anti-phasic gene expression between mouse and human enteroids.

DoubletDecon identifies and removes doublets from scRNA-seq data using deconvolution and gene expression analysis.

The paper introduces an improved clustering algorithm for scRNA-seq data that outperforms existing methods on benchmark datasets and scales to large-scale data.

cellHarmony matches and compares single-cell transcriptomes to identify disease-specific gene regulatory programs and cell-state changes.