p53 activity licenses transcriptional regulation by YAP/TAZ-TEAD to shape expression landscapes during tumorigenesis
Cole P Martin, Scott Bang, William B. Sullivan, Joseph R Gomes, Matthew David Smith, Cheng Fan, A. Cole Edwards, Channing J. Der, Yusha Liu, John P. Morris
The paper shows that p53 activity regulates YAP/TAZ-TEAD complexes to shape transcriptional landscapes during tumorigenesis by altering TEAD binding and gene regulatory networks.
bioRxiv · Sep 29, 2025 · PreprintCancer Biology