William B. Sullivan

This study shows that p53 and YAP/TAZ-TEAD activities regulate metaplastic heterogeneity in pancreatic cancer by influencing differentiation states and molecular subtypes.

The paper shows that p53 activity regulates YAP/TAZ-TEAD complexes to shape transcriptional landscapes during tumorigenesis by altering TEAD binding and gene regulatory networks.

This paper shows that mutant IDH disrupts p53 target gene regulation by altering chromatin states, disabling tumor suppression, and that this effect can be reversed with IDH inhibition.