Yusha Liu

The paper uses a multiplexed single-cell multiome approach to identify a molecular signature of insulin-driven asthma in adults with high early-life insulin levels.

This study shows that p53 and YAP/TAZ-TEAD activities regulate metaplastic heterogeneity in pancreatic cancer by influencing differentiation states and molecular subtypes.

The paper shows that p53 activity regulates YAP/TAZ-TEAD complexes to shape transcriptional landscapes during tumorigenesis by altering TEAD binding and gene regulatory networks.

This paper introduces GBCD to decompose tumor transcriptional heterogeneity in scRNA-seq data, identifying a new prognostic gene expression program in pancreatic cancer.