Pharmacology & ToxicologybioRxivPreprint
Selective degradation of multimeric proteins via chemically induced proximity to TRIM21
Panrui Lu, Yalong Cheng, Lei Xue…·Ting Han
This study identifies acepromazine as a compound that selectively degrades multimeric proteins via TRIM21 activation, offering a new strategy for targeting disease-related protein assemblies.
DOI 10.1101/2024.01.31.578122