Jia Li

Normobaric hypoxia alters the transcriptional response of healthy human skeletal muscles to a single session of high-intensity interval exercise

This study examines how normobaric hypoxia affects gene expression in skeletal muscle after high-intensity interval exercise, finding more differentially expressed genes in hypoxia at 24 h post-exercise.

Indazolone-Based Molecular Glue Degraders as a Tunable Platform for Reprogramming Cereblon Substrate Specificity

This paper introduces an indazolone-based platform for CRBN molecular glue degraders, enabling tunable substrate specificity and broad therapeutic potential.

Comprehensive long-read transcriptome analysis uncovers alternative RNA processing feature and isoform diversity in ovarian cancer progression

The paper uses long-read RNA sequencing to analyze isoform diversity in ovarian cancer, identifying key isoform-level changes associated with disease progression and clinical outcomes.

Antarctic marine microplastics reveals environmental persistence and rapid evolution of Candida auris

The paper isolates Candida auris from Antarctica, identifies cold-adapted traits, and links mutator phenotypes to rapid evolution and drug resistance in global C. auris clades.

Instantaneous Beta Frequency Regulates Self-Generated Timing in Humans

This study shows that instantaneous beta frequency in humans dynamically controls self-generated timing by predicting duration production.

AI recognizes convergent somatic hypermutation signatures to allow the discovery of variant-resilient broadly neutralizing antibodies

The paper uses AI to identify convergent somatic hypermutation patterns in antibodies, enabling the discovery of variant-resilient broadly neutralizing antibodies from early-pandemic data.

Exploring the potential value of aloe active components in inhibiting non-small cell lung cancer through network pharmacology

This study uses network pharmacology to identify Aloe vera compounds that target NSCLC through multiple pathways and proteins, suggesting potential for new anticancer therapies.

Multiple-level organizational logic of the locus coeruleus-norepinephrine system in structure and function

The paper reveals how locus coeruleus-norepinephrine neurons organize to regulate brain-wide neural dynamics through region-specific axon projections and synchronized firing.

Incidental identification of maternal malignancies in two Asian women underwent noninvasive prenatal test

This study reports two cases of maternal malignancies detected incidentally during noninvasive prenatal tests in Asian women, showing concordant genome disruption patterns between tumor samples and NIPT results.