Three positively charged binding sites on the eastern equine encephalitis virus E2 glycoprotein coordinate heparan sulfate- and protein receptor-dependent infection
Maria D. H. Alcorn, Chengqun Sun, Theron C. Gilliland, Tetyana Lukash, Christine M. Crasto, Saravanan Raju, Michael Diamond, Scott C. Weaver, William B. Klimstra
This study identifies three HS-binding sites on EEEV E2 glycoprotein that contribute to both HS and protein receptor-dependent infection, affecting disease and mosquito infectivity.
Nature Communications · Aug 5, 2025Peer-reviewedMicrobiology