Master transcription factor binding sites constitute the core of early replication control elements
Jesse L. Turner, Laura Hinojosa-Gonzalez, Takayo Sasaki, Satoshi Uchino, Athanasios E Vouzas, Mariella S Soto, Abhijit Chakraborty, Karen E. Alexander, Cheryl A. Fitch, Amber N. Brown, Ferhat Ay, David M. Gilbert
The paper identifies subERCEs as master transcription factor binding sites that drive early replication timing and transcription in mESCs, functioning as both enhancers and structural chromatin organizers.
The EMBO Journal · Jul 17, 2025Peer-reviewedMolecular Biology