Karen E. Alexander

This study identifies Dfm1 as a key factor in Ste24-dependent translocon quality control, showing that its loss increases toxicity of clogged translocon substrates.

The paper identifies subERCEs as master transcription factor binding sites that drive early replication timing and transcription in mESCs, functioning as both enhancers and structural chromatin organizers.

The paper manipulates transcription to show it can advance replication timing but is not required for the switch to early replication.