Satoshi Uchino

The paper shows that chromatin modifications around genes fluctuate with transcriptional activity in mouse embryonic stem cells, revealing minute-scale coupling between histone marks and transcriptional bursts.

The paper identifies subERCEs as master transcription factor binding sites that drive early replication timing and transcription in mESCs, functioning as both enhancers and structural chromatin organizers.

The paper uses single-molecule imaging to show RNA fluctuations modulate SOX2 dynamics at the Nanog locus, revealing RNA-dependent feedback in transcriptional regulation.

The paper develops a STREAMING-tag system to study spatiotemporal relationships between transcriptional factors and activity in living cells.