Integrating activation-induced costimulation and cytokine signals enhance TCR-based cell therapies
Mansi Narula, Johannes Englisch, Cheryl Ou, Tadahiro Honda, Ismael De La Iglesia San Sebastián, Azlann Arnett, Feiyan Mo, Maksim Mamonkin, Norihiro Watanabe
This study develops a dual stimulatory receptor (DSR) to enhance TCR-based cell therapies by delivering signals 2 and 3, improving T cell expansion and antitumor activity in xenograft models.
bioRxiv · Jul 17, 2026 · PreprintImmunology