Proteostatic significance of helix O alanine residues in CLC channels
Chia-Ying You, Ciao‐Yu Zhong, Pei-Chen Tsai, An-Ting Cheng, Yuehua Chen, Chung‐Jiuan Jeng, Chih‐Yung Tang
This study examines the role of helix O alanine residues in CLC channels, showing that mutations at these sites cause proteostatic defects and impair channel function.
bioRxiv · May 28, 2026 · PreprintCell Biology