Yuehua Chen

This paper develops a 2-locus CRISPR toxin-antidote gene drive system that improves confinement by increasing the introduction threshold for population modification.

This study identifies IL-21-producing Tph cells in tertiary lymphoid structures of biliary atresia patients and shows IL-21R blockade reduces disease severity in a mouse model.

This study identifies March5 as a muscle proteostatic checkpoint that limits ATF4-dependent GDF15 production, linking muscle health to feeding and body composition.

This paper introduces a vascular chip that enables controlled experimentation with disease-relevant wall shear stress topology, revealing its effects on endothelial mechanics and function.

mirCCC infers microRNA-mediated cell-cell communication from single-cell RNA sequencing by detecting coordinated gene expression changes and models miRNA activity and transfer capacity.

This study shows that cultivating Gracilariopsis lemaneiformis boosts carbon sequestration in coastal sediments by altering microbial communities and enhancing carbon cycling efficiency.

eRNAformer maps enhancer-derived RNA loci genome-wide using deep learning, identifying new eRNA loci linked to disease risk and cancer therapy.

This study shows that ROS inhibit mitophagy by activating PARP1, which PARylates PINK1 and impairs its function.

This study examines energy metabolic changes in aging male bone marrow mesenchymal stem cells and identifies gene expression and metabolic shifts associated with senescence.

HOMED improves DNA methylation deconvolution by integrating cell-lineage hierarchies and single-cell data, achieving higher accuracy across tissues.

The paper shows Rab8a-dependent vesicular trafficking transports Wnt8a along cytonemes in zebrafish embryos, affecting Wnt signaling and embryonic patterning.

This study identifies IFN homologs in jawless vertebrates and demonstrates their antiviral function, tracing the evolutionary origin of IFN to basal chordates.

The paper identifies a phage-encoded small RNA that mimics the CRISPR-Cas9 guide RNA to inhibit the system and demonstrates its reprogrammability for DNA cleavage and trans-cleavage.

This study examines the role of helix O alanine residues in CLC channels, showing that mutations at these sites cause proteostatic defects and impair channel function.

The paper shows M1 macrophages drive lymphangiogenesis in liver fibrosis via MDK/YAP signaling, worsening fibrosis.

This study identifies the enzymatic pathway for bisbenzylisoquinoline alkaloid biosynthesis and reveals a non-canonical redox-mediated mechanism for stereochemical control.

This paper introduces a computational framework for true 3D spatial reconstruction of tissues, demonstrating improved fidelity over 2D methods across multiple spatial omics modalities.

AM-DMF-SCP-pro enables rapid, low-background single-cell proteome profiling in complex samples by streamlining sample preparation and reducing background interference.

This study creates a single-cell RNA sequencing atlas of mouse nasal development, identifying cell clusters and subtypes, and revealing regulators of lineage specification.

The paper identifies cell-type-specific vagal and enteric circuits that control meal-induced gastric secretion and shows segregation of secretory and motor functions.

This study reconstructs 3D spatial transcriptomic models of planarians to map cell type distribution and positional gene regulation, identifying candidate genes involved in regeneration.

The paper identifies BN3 as a broad-spectrum agent that accelerates emergence from general anesthesia by targeting a VTA glutamatergic arousal circuit.