Membrane localisation and checkpoint blockade enhance xenoantigen delivery to redirect pre-existing immunity against tumours
Sylvie Hauert, Fuxin Zhou, Justas Šidiškis, Aishwarya Saxena, Zoe Goldberger, Kevin Chang, Chiara Kling, Natalie Köhler, Stefan Fichtner‐Feigl, Jeffrey A. Hubbell, Huda Jumaa, Priscilla S. Briquez
This study shows that membrane-localized xenoantigens enhance CD4+ T cell responses and improve anti-PD-1 therapy efficacy in pre-immunized mice, using OVA and VZV gE antigens.
bioRxiv · Mar 3, 2026 · PreprintCancer Biology