Gαq sensitizes TRPM8 to inhibition by PI(4,5)P2 depletion upon receptor activation
Luyu Liu, Yevgen K. Yudin, Janhavi Nagwekar, Chifei Kang, Natalia Shirokova, Tibor Rohács
The paper shows that Gαq inhibits TRPM8 by reducing its affinity for PI(4,5)P2, making it more sensitive to PI(4,5)P2 depletion upon GPCR activation.
Journal of Neuroscience · May 24, 2019Peer-reviewedNeuroscience