Tibor Rohács

Omega-3 Fatty Acid Derived Neuroactive Lipids - Docosahexaenoyl-Glycine and Its Epoxide Metabolites are Multifunctional Lipid Mediators

The paper identifies NA-Gly, DHA-Gly, and their epoxide derivatives as multifunctional lipid mediators with anti-inflammatory properties and selective receptor modulation, suggesting therapeutic potential for neuroinflammation.

Phosphatidic acid is an endogenous negative regulator of PIEZO2 channels and mechanical sensitivity

The paper identifies phosphatidic acid and its analogues as lipid regulators that selectively inhibit PIEZO2 channels, revealing the PLD pathway's role in modulating PIEZO2 activity and mechanical sensitivity.

TMEM120A/TACAN inhibits mechanically activated Piezo2 channels

The paper shows TACAN inhibits Piezo2 channel activity in DRG neurons without affecting Piezo1 or TREK1 currents.

Disease-associated mutations in TRPM3 render the channel overactive via two distinct mechanisms

The paper shows two disease-associated TRPM3 mutations cause overactivity through distinct mechanisms, with potential therapeutic implications using primidone.

Gi-Coupled Receptor Activation Potentiates Piezo2 Currents via Gβγ

This study shows that Gi-coupled receptor activation enhances Piezo2 currents through Gβγ signaling in DRG neurons and heterologous systems.

Gαq sensitizes TRPM8 to inhibition by PI(4,5)P2 depletion upon receptor activation

The paper shows that Gαq inhibits TRPM8 by reducing its affinity for PI(4,5)P2, making it more sensitive to PI(4,5)P2 depletion upon GPCR activation.