Spindle size scaling secures mitotic fidelity against whole-genome doubling-associated mechanical stress
Qijiao Wang, Chiharu Watanabe, Sumire Ishida‐Ishihara, Yukako Nishimura, Takahiro Yamamoto, Fumio Motegi, Ryota Uehara
This study shows that whole-genome doubling increases mechanical stress on mitotic spindles, which is mitigated by spindle elongation to maintain mitotic fidelity.
bioRxiv · Oct 12, 2026 · PreprintCell Biology