Ryota Uehara

This study shows that whole-genome doubling increases mechanical stress on mitotic spindles, which is mitigated by spindle elongation to maintain mitotic fidelity.

The paper uses live-imaging to study proliferation dynamics of post-WGD HCT116 cell lineages, finding that multipolar chromosome segregation limits proliferative capacity.

This study shows that mitotic slippage and cytokinesis failure, two mechanisms of whole-genome duplication, differentially affect post-WGD cell viability through distinct chromosome segregation patterns.

This study identifies Cep192 insufficiency as a cause of haploid instability in human cells and shows that restoring Cep192 or enhancing the acentrosomal spindle pathway stabilizes haploid cells.

This study identifies ER stress-induced proteotoxicity as a key factor causing haploid instability in human somatic cells, showing that haploids are more prone to apoptosis due to inefficient proteostasis.

This study identifies mitotic defects and cell death in haploid zebrafish larvae as key factors limiting larval growth, revealing a conserved cellular mechanism across vertebrates.