Sumire Ishida‐Ishihara

This study shows that whole-genome doubling increases mechanical stress on mitotic spindles, which is mitigated by spindle elongation to maintain mitotic fidelity.

The paper uses live-imaging to study proliferation dynamics of post-WGD HCT116 cell lineages, finding that multipolar chromosome segregation limits proliferative capacity.

This study identifies ER stress-induced proteotoxicity as a key factor causing haploid instability in human somatic cells, showing that haploids are more prone to apoptosis due to inefficient proteostasis.