Activation of prefrontal parvalbumin interneurons ameliorates treatment-resistant working memory deficit even under continuous antipsychotic treatment in a mouse model of schizophrenia
Yosefu Arime, Yoshito Saitoh, Mikiko Ishikawa, Chikako Kamiyoshihara, Yasuo Uchida, Kazuki Fujii, Keizo Takao, Kazufumi Akiyama, Noriaki Ohkawa
This study shows that activating prefrontal parvalbumin interneurons improves working memory deficits in a mouse model of schizophrenia, even when mice are continuously treated with antipsychotics.
bioRxiv · Feb 27, 2023 · PreprintNeuroscience