Author

Keizo Takao

University of ToyamaORCID 0000-0002-4734-3583Unclaimed ORCID profile · follow to get notified of new preprints

Biology Disciplines

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Signature Assays, Organisms & Methods

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Organism:mouse· 7 Approach:experimental assay· 5 Research Focus:benchmarking· 2 Approach:statistical model· 2 Assay:bulk RNA-seq· 1 Research Focus:cell type annotation· 1 Research Focus:cell-cell communication· 1 Research Focus:differential expression· 1

Frequent Co-Authors

Tsuyoshi MiyakawaiD· 3 shared Akinobu MatsumotoiD· 2 shared Giovanni SalaiD· 2 shared Hideo HagiharaiD· 2 shared Hiroshi AgetaiD· 2 shared Hirotaka ShojiiD· 2 shared Izuho HatadaiD· 2 shared Kaoru InokuchiiD· 2 shared

Activity by Year

2018-2026 · peak 2/yr

Co-Author Collaboration Network

10 top collaborators · 45 mutual co-author links

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3 shared papersNeuroscience

Tsuyoshi MiyakawaORCID

Mutual co-authors in cluster

Author profile →

7 papers

Recent·Most cited

Repetitive Neuronal Activation Regulates Cellular Maturation State via Nuclear Reprogramming

Tomoyuki Murano, Hideo Hagihara, Katsunori Tajinda, Keizo Takao, Yoshihiro Takamiya, Kaoru Katoh, Alfred Jay Robison, Mitsuyuki Matsumoto, Masakazu Namihira, Tsuyoshi Miyakawa

The paper shows that repetitive neuronal activation induces nuclear reprogramming, leading to cellular maturation state changes with behavioral effects similar to ECT.

Nature Communications · Jul 17, 2026Peer-reviewedNeuroscience

Large-scale dimensional behavioral profiling dissociates fear memory from locomotor confounds in mice: The necessity of baseline-normalized metrics

Daiki X. Sato, Markos Michail Chatzigiannis, Hirotaka Shoji, Giovanni Sala, Satoko Hattori, Keizo Takao, Tatsuo Kinashi, Tatsuya Kishino, Sumiyo Morita, Izuho Hatada, Yo Shinoda, Kotaro Hattori, Takeshi Yagi, Akinobu Matsumoto, Hideo Egawa, , Tsuyoshi Miyakawa

The paper demonstrates that baseline-normalized metrics are essential for accurately interpreting fear memory in mice, showing that conventional freezing scores confound locomotor activity.

bioRxiv · Jul 17, 2026 · PreprintNeuroscience

Large-scale animal model study uncovers altered brain pH and lactate levels as a transdiagnostic endophenotype of neuropsychiatric disorders involving cognitive impairment

Hideo Hagihara, Hirotaka Shoji, Satoko Hattori, Giovanni Sala, Yoshihiro Takamiya, Mika Tanaka, Masafumi Ihara, Mihiro Shibutani, Izuho Hatada, Kei Hori, Mikio Hoshino, Akito Nakao, Yasuo Mori, Shigeo Okabe, Masayuki Matsushita, , Michihiro Igarashi

The paper investigates brain pH and lactate levels in animal models of neuropsychiatric disorders, finding decreased pH and increased lactate levels as common features across multiple models.

eLife · Sep 1, 2023Peer-reviewedNeuroscience

Activation of prefrontal parvalbumin interneurons ameliorates treatment-resistant working memory deficit even under continuous antipsychotic treatment in a mouse model of schizophrenia

Yosefu Arime, Yoshito Saitoh, Mikiko Ishikawa, Chikako Kamiyoshihara, Yasuo Uchida, Kazuki Fujii, Keizo Takao, Kazufumi Akiyama, Noriaki Ohkawa

This study shows that activating prefrontal parvalbumin interneurons improves working memory deficits in a mouse model of schizophrenia, even when mice are continuously treated with antipsychotics.

bioRxiv · Feb 27, 2023 · PreprintNeuroscience

Inhibiting proBDNF to mature BDNF conversion leads to autism-like phenotypes in vivo

He You, Toshiyuki Mizui, Kazuyuki Kiyosue, Keizo Takao, Tsuyoshi Miyakawa, Koichi Kato, Mitsuru Otsuka, Ting Bai, Kun Xia, Bai Lu, Masami Kojima

This study shows that inhibiting proBDNF to mBDNF conversion in mice leads to autism-like behaviors, suggesting proBDNF as a potential blood marker and therapeutic target for ASD.

bioRxiv · Jun 12, 2020 · PreprintNeuroscience

GluD1 knockout mice with a pure C57BL/6N background show impaired fear memory, social interaction, and enhanced depressive-like behavior

Chihiro Nakamoto, Meiko Kawamura, Ena Nakatsukasa, Rie Natsume, Keizo Takao, Masahiko Watanabe, Manabu Abe, Tomonori Takeuchi, Kenji Sakimura

This study shows that GluD1 knockout mice exhibit impaired fear memory, reduced sociability, and enhanced depressive-like behavior, with antidepressant effects observed with serotonin reuptake inhibitors.

PLoS ONE · Feb 20, 2020Peer-reviewedNeuroscience

Autonomous functionality of an upstream open reading frame in polycistronic mammalian mRNAs

Shohei Kitano, Gabriel Pratt, Keizo Takao, Yasunori Aizawa

The paper identifies a uORF in mammalian mRNAs that functions independently of its downstream anORF, challenging the monocistronic gene model.

bioRxiv · May 30, 2018 · PreprintMolecular Biology