Correlative evaluation of anticancer effects of a modified methioninase MGL-KPV using 2D and 3D cell models, human cancer xenografts in zebrafish embryos and Balb/c nude mice
Irina I. Khan, Saida Sh. Karshieva, Darina V. Sokolova, Chingis Aidossov, Yulia A. Borisova, Nikolay A. Bondarev, Anna V. Kudryavtseva, Sergey V. Bazhenov, И. В. Манухов, Vadim S. Pokrovsky
This study evaluates the anticancer effects of MGL-KPV across 2D/3D cell models, zebrafish xenografts, and mice, showing significant tumor reduction and selective cytotoxicity.
bioRxiv · Dec 25, 2025 · PreprintPharmacology & Toxicology