Novel approaches to quantify defective interfering particle activity reveal a surrogate marker of interference in mammarenaviruses
Rebekah Honce, Inessa Manuelyan, Chloe Schiff, E. van Beek, Kanayo Ikeh, Allysen Henriksen, Philip L. Eisenhauer, Jason Botten
This paper develops new methods to measure defective interfering particle (DIP) activity in mammarenaviruses, identifying a surrogate marker of interference through glycoprotein expression loss.
bioRxiv · Sep 28, 2026 · PreprintMicrobiology