Dietary lipid stress aggravates obstructive lung injury involving epithelial IGF-1-Akt dysfunction and epithelial-endothelial crosstalk
Choyo Ogasawara, Hirofumi Nohara, Tomoki Kishimoto, Keisuke Kawano, Kenji Watanabe, Kentaro Oniki, Yukio Fujiwara, Ryunosuke Nakashima, Shunsuke Kamei, Noriki TAKAHASHI, Megumi Hayashi, Ayami Fukuyama, Mai Uemura, Keiko Ueno-Shuto, Junji Saruwatari, , Tsuyoshi Shuto
This study shows that high-fat diet worsens obstructive lung injury by impairing epithelial IGF-1-Akt signaling and promoting epithelial-endothelial interactions.
bioRxiv · Sep 3, 2026 · PreprintMolecular Biology