Pilot study demonstrating changes in DNA hydroxymethylation enable detection of multiple cancers in plasma cell-free DNA
Anna Bergamaschi, Yuhong Ning, Chin‐Jen Ku, Chris Ellison, François Collin, Gulfem Dilek Guler, Tierney C. Phillips, Erin McCarthy, Wendy Wang, Michael Antoine, Aaron Scott, Paul Lloyd, Alan Ashworth, Steve R. Quake, Samuel Levy
This study uses 5-hydroxymethyl cytosine (5hmC) profiles in plasma cell-free DNA to detect multiple cancers with high accuracy using machine learning.
medRxiv · Jan 22, 2020 · PreprintGenetic & Genomic Medicine