Most human DNA replication initiation is dispersed throughout the genome with only a minority within previously identified initiation zones
Jamie T. Carrington, Rosemary H. C. Wilson, Eduardo de La Vega, Sathish Thiyagarajan, Tom Barker, Leah Catchpole, Alex Durrant, Vanda Knitlhoffer, Chris Watkins, Karim Gharbi, Conrad A. Nieduszynski
The paper uses single-molecule sequencing to show most DNA replication initiation in human cells occurs at dispersed sites, not just previously identified zones.
Genome biology · May 9, 2025Peer-reviewedGenomics