Altered Hepatic Metabolism in Down Syndrome
Lauren N. Dunn, Brian F. Niemeyer, Neetha Paul Eduthan, Kyndal A. Schade, Katherine A. Waugh, Chrisstopher Brown, Angela L. Rachubinski, Ariel E. Timkovich, David J. Orlicky, Matthew D. Galbraith, Joaquin Maximiliano Espinosa, Kelly D. Sullivan
The paper reports altered hepatic metabolism in Down syndrome using multi-omic analysis of plasma and mouse models, showing increased bile acids and liver dysfunction that can be modulated by diet.
Cell Reports · Jan 1, 2026Peer-reviewedGenetics