Author

Kyndal A. Schade

University of Colorado Anschutz

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

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Genetics· 2 Genomics· 1

Signature Assays, Organisms & Methods

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Assay:bulk RNA-seq· 3 Organism:mouse· 3 Research Focus:cell type annotation· 2 Research Focus:differential expression· 2 Organism:human· 2 Approach:statistical model· 2 Approach:experimental assay· 1 Research Focus:gene regulatory network inference· 1

Frequent Co-Authors

Angela L. RachubinskiiD· 3 shared Joaquin Maximiliano EspinosaiD· 3 shared Kelly D. SullivaniD· 3 shared Lauren N. DunniD· 3 shared Matthew D. GalbraithiD· 3 shared Ariel E. TimkovichiD· 2 shared David J. OrlickyiD· 2 shared Katherine A. WaughiD· 2 shared

Activity by Year

2022-2026 · peak 2/yr

Co-Author Collaboration Network

10 top collaborators · 44 mutual co-author links

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3 shared papersGenetics

Angela L. RachubinskiORCID

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3 papers

Recent·Most cited

A Trisomy 21 Model Atlas reveals conserved dosage effects and context-specific transcriptional responses across mouse and human models of Down syndrome

Karen Rossmassler, Ariel E. Timkovich, Brian Niemeyer, Kyndal A. Schade, Lauren N. Dunn, Macallister C. Harris, R Adam Harris, Srija Chillamcherla, Angela L. Rachubinski, Joaquin Maximiliano Espinosa, Kelly D. Sullivan, Matthew D. Galbraith

The paper presents a Trisomy 21 Model Atlas comparing mouse and human models to show conserved dosage effects and context-specific transcriptional responses across tissues and developmental stages.

bioRxiv · Oct 14, 2026 · PreprintGenomics

Altered Hepatic Metabolism in Down Syndrome

Lauren N. Dunn, Brian F. Niemeyer, Neetha Paul Eduthan, Kyndal A. Schade, Katherine A. Waugh, Chrisstopher Brown, Angela L. Rachubinski, Ariel E. Timkovich, David J. Orlicky, Matthew D. Galbraith, Joaquin Maximiliano Espinosa, Kelly D. Sullivan

The paper reports altered hepatic metabolism in Down syndrome using multi-omic analysis of plasma and mouse models, showing increased bile acids and liver dysfunction that can be modulated by diet.

Cell Reports · Jan 1, 2026Peer-reviewedGenetics

Interferon receptor gene dosage determines multiple hallmarks of Down syndrome

Katherine A. Waugh, Ross Minter, Jessica A Baxter, Congwu Chi, Kathryn D. Tuttle, Neetha Paul Eduthan, Matthew D. Galbraith, Kohl T. Kinning, Zdeněk Andrysík, Paula Araya, Hannah Dougherty, Lauren N. Dunn, Michael P. Ludwig, Kyndal A. Schade, Dayna Tracy, , Joaquin Maximiliano Espinosa

The paper shows that correcting interferon receptor gene dosage in a mouse model of trisomy 21 rescues multiple key phenotypes associated with Down syndrome.

bioRxiv · Feb 3, 2022 · PreprintGenetics