David J. Orlicky

This study shows HS3ST1 deficiency worsens lung injury and increases mortality after trauma and hemorrhagic shock, particularly with fresh frozen plasma resuscitation.

The paper reports altered hepatic metabolism in Down syndrome using multi-omic analysis of plasma and mouse models, showing increased bile acids and liver dysfunction that can be modulated by diet.

This study shows that epithelial HO-1 promotes colonic tumorigenesis in chronic inflammation by increasing iron availability and oxidative stress, while protecting against acute heme toxicity.

This study shows that lung epithelial cells promote breast cancer metastasis through wound repair mechanisms, and targeting CREB signaling with PDE4 inhibitors can reduce metastatic outgrowth.

This study identifies antigen-driven CD8+ T cell clonal expansion in human and mouse MASH, showing their activation and functional differentiation in liver disease.

This study shows oxidative stress in mouse lenses increases cytokine expression and immune cell presence, linking it to inflammation and posterior capsule opacification.

The paper shows that correcting interferon receptor gene dosage in a mouse model of trisomy 21 rescues multiple key phenotypes associated with Down syndrome.

This study shows that Gclc deletion in surface-ectoderm tissues causes microphthalmia in mice and zebrafish, indicating a conserved role in eye development.