The Structural Basis of Malodorant Skatole Formation by the Glycyl Radical Enzyme Indoleacetate Decarboxylase
Christa N. Imrich, Lindsey R. F. Backman, Abigail P. Allworth, Mary C. Andorfer, Jared C. Paris, Nina M. Greeley, Beverly Fu, Emily P. Balskus, Catherine Luschinsky Drennan
This paper determines the structure of indoleacetate decarboxylase and challenges the proposed mechanism of skatole formation by showing it may follow a Kolbe-type decarboxylation rather than hydrogen atom transfer.
Proceedings of the National Academy of Sciences · Sep 18, 2026Peer-reviewedBiochemistry