BiochemistryProceedings of the National Academy of SciencesPeer-reviewed
The Structural Basis of Malodorant Skatole Formation by the Glycyl Radical Enzyme Indoleacetate Decarboxylase
Christa N. Imrich, Lindsey R. F. Backman, Abigail P. Allworth…·Catherine Luschinsky Drennan
This paper determines the structure of indoleacetate decarboxylase and challenges the proposed mechanism of skatole formation by showing it may follow a Kolbe-type decarboxylation rather than hydrogen atom transfer.
DOI 10.1073/pnas.2618341123