Solving the trade-off by differences in handling of intracellular K+: why substrate translocation by the dopamine transporter but not by the serotonin transporter is voltage-dependent
Shreyas Bhat, Marco Niello, Klaus Schicker, Christian Pifl, Harald H Sitte, Michael Freissmuth, Walter Sandtner
The paper compares dopamine and serotonin transporters, showing DAT uptake is voltage-dependent while SERT is not, due to differences in ion binding kinetics.
bioRxiv · Jul 9, 2020 · PreprintBiophysics