A nucleotide-triggered molecular switch orchestrating septin polymerization
Benjamin Grupp, Benjamin Jäckel, Assmann Gunter, Jakob Rehberger, Stefan Steimle, Jan Felix Gehrke, Christian Sieg, Jan Strittmatter, Tobias Wunder, Thomas Vomhof, Johannes Ruhnke, Erik Schleicher, S. Gerhardt, Nils Johnsson, Thomas Gronemeyer
This study identifies a nucleotide-triggered mechanism that stabilizes the G-interface and enables NC-interface assembly in septins, revealing unidirectional allosteric signaling during filament formation.
bioRxiv · May 11, 2026 · PreprintMolecular Biology