Nuclear Phase Separation Drives NPM1-mutant Acute Myeloid Leukemia
Gandhar K. Datar, Elmira Khabusheva, Archish Anand, Joshua Beale, Marwa Sadek, Chun-Wei David Chen, Evdokiia Potolitsyna, Nayara Sousa de Alcântara-Contessoto, Guangyuan Liu, Josephine De La Fuente, Christina Dollinger, Anna G. Guzman, Alejandra G. Martell, Katharina Wohlan, Abhishek Maiti, , Joshua A. Riback
This study shows that mutant NPM1 forms nuclear condensates called C-bodies, which are essential for leukemic gene expression and cell survival, and identifies them as potential therapeutic targets.
Cell · Nov 4, 2025Peer-reviewedBiophysics