Brunangelo Falini

This study shows that mutant NPM1 forms nuclear condensates called C-bodies, which are essential for leukemic gene expression and cell survival, and identifies them as potential therapeutic targets.

This paper shows that high-grade B cell lymphomas with MYC and BCL2 rearrangements originate from BCR-silenced follicular lymphoma cells that acquire IGL::MYC translocations, leading to resistance to CD79B-targeting therapy.

SiCoDEA is an open-source app for analyzing drug effects and combinations, offering multiple models and visualization tools to assess synergy, antagonism, and additivity.